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Flomax dosing schedule

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Dosing & Uses

AdultPediatric

flomax Dosage Forms & Strengths

capsule

  • 0.4mg

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Benign Prostatic Hypertrophy

0.4 mg PO once daily, 30 minutes after same meal each day; if response is inadequate after 2-4 weeks, may be increased to 0.8 mg once daily; if therapy is interrupted, should be resumed at 0.4 mg once daily

Bladder Outlet Obstruction

Relief of symptoms

0.4 mg PO once daily

Ureteral Stones

Facilitation of stone expulsion

0.4 mg PO once daily; discontinued after successful expulsion (average, 1-2 weeks)

Dosing Modifications

Renal impairment

  • CrCl ≥10 mL/min: Dosage adjustment not necessary
  • CrCl <10 mL/min: Not studied

Hepatic impairment

  • Mild to moderate: Dosage adjustment not necessary
  • Severe: Not studied

Safety and efficacy not established

Interactions

Interaction Checker

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Adverse Effects

>10%

Headache (19-21%)

Orthostatic hypotension (6-19%)

Rhinitis (13-18%)

Abnormal ejaculation (8-18%)

Dizziness (15-17%)

Arthralgia (11%)

Infection (9-11%)

1-10%

Asthenia (8%)

Back pain (7-8%)

Skin rash (7%)

Pharyngitis (5-6%)

Diarrhea (4-6%)

Myalgia (5%)

Chest pain (4%)

Cough (3-4%)

Somnolence (3-4%)

Nausea (2-4%)

Sinusitis (2-4%)

Abdominal discomfort (2-3%)

Bitter taste (2-3%)

Decreased libido (1-2%)

Insomnia (1-2%)

Postmarketing Reports

Priapism (rare)

Signs and symptoms of orthostasis, including syncope

Infrequent reports of dyspnea, palpitations, hypotension, atrial fibrillation, arrhythmia, and tachycardia

Visual impairment

During cataract and glaucoma surgery, a variant of small pupil syndrome known as Intraoperative Floppy Iris Syndrome (IFIS) has been reported in association with alpha1 flomax dosing schedule blocker therapy

Skin desquamation including reports of Stevens-Johnson syndrome, erythema multiforme, and dermatitis exfoliative

Constipation, vomiting, and epistaxis

Allergic-type reactions (eg, skin rash, urticaria, pruritus, angioedema, respiratory symptoms) have been reported with positive rechallenge

Dry mouth

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Warnings

Contraindications

Hypersensitivity

Cautions

Use with caution in coronary artery disease, liver disease, general anesthesia

Orthostatic hypotension may occur

Priapism rarely reported

Prostatic cancer should be ruled out before therapy is initiated

May cause syncope (first-dose effect)

Discontinue if angina symptoms occur or worsen

Intraoperative floppy iris syndrome has been reported in patients receiving alpha1 blockers at time of cataract surgery; association is unclear

Patients with sulfa allergy have rarely developed allergic reaction; avoid use if previous sulfa allergy reactions have been life-threatening

Not for use as antihypertensive drug

May exacerbate heart failure

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Pregnancy & Lactation

Pregnancy category: B

Lactation: Women are unlikely to use drug

Pregnancy Categories

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Pharmacology

Mechanism of Action

Blocks alpha1a adrenergic receptor in smooth muscle of prostate, decreasing bladder neck and urethral resistance

Absorption

Bioavailability: Fasting, 30%

Onset: 4-8 hr

Peak plasma time: With food, 6-7 hr; fasting, 4-5 hr

Distribution

Protein bound: 90%

Vd: 0.2 L/kg or 16 L

Metabolism

Metabolized in liver

Metabolites: Glucuronide and sulfate conjugates (inactive)

Elimination

Half-life: 14-15 hr

Excretion: Urine (76%), feces (21%)

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Patient Handout

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Formulary

FormularyPatient Discounts

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Create Your List of Plans

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier Description 1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs. 2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs. 3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs. 4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. 5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. 6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. NC NOT COVERED – Drugs that are not covered by the plan. Code Definition PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription. QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered. ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription. OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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